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June 8th, 2022 | 11:35 CEST

Valneva, Defence Therapeutics, Bayer - Blockbusters: Turbos for your share portfolio!

  • Biotechnology
  • Vaccination
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Blockbusters are drugs with which companies generate sales of more than USD 1 billion per year. Corona vaccines are currently an integral part of the global hit list. But also many application areas in different cancer fields or cardiovascular diseases offer a large market worth billions. Like BioNTech, a company with the right pipeline and the resulting compounds can quickly evolve from a start-up into an established and profitable player.

time to read: 3 minutes | Author: Carsten Mainitz

Table of contents:

    David Elsley, CEO, Cardiol Therapeutics Inc.
    "[...] As a company dedicated to developing treatments for rare heart diseases, we see this as an opportune moment to contribute to the fight against heart disease and make meaningful strides in improving heart health worldwide. [...]" David Elsley, CEO, Cardiol Therapeutics Inc.

    Full interview


    Valneva - Still in play

    The long wait continues. While the responsible regulatory authority in the UK, MHRA, was the first to approve the Corona vaccine of the French pharmaceutical company Valneva back in April, the situation in the EU is much more difficult. These uncertainties have led to great volatility in share prices in recent weeks and months.

    Although the European Medicines Agency, EMA, accepted the marketing authorization application for the vaccine VLA2001, it is still examining, and has been doing so since last December, whether approval will be granted. If the EMA gives the thumbs up, the EU still has to give its approval, but this is generally regarded as a mere formality. The French vaccine would then be the fifth approved vaccine in the EU.

    The Valneva vaccine is the first non-mRNA vaccine to be launched on the market. It contains inactive, i.e. killed viruses. These cannot lead to infection or disease, but they stimulate the formation of immune substances. It is referred to as a dead vaccine. The hope is often expressed that previous opponents of vaccination will become more sympathetic to this proven vaccination method.

    Analysts are confident about the Company and formulate average price targets corresponding to an upside potential of just under 80%. For the current fiscal year, the experts still expect the Company to be in the red with sales of EUR 343 million. In 2023, revenues are expected to rise to EUR 1.2 billion. The 2023 P/E ratio is a moderate 6.

    Defence Therapeutics - Impressive news

    Biotech company Defence Therapeutics focuses on immuno-oncology and infectious disease research. With the help of the proprietary and patented Accum technology, the Canadians have the potential to bring blockbusters to market in the future.

    In May, Defence Therapeutics published very good results for its novel vaccine ACCUVAC-PTE7, which was developed based on Accum technology. A complete protective effect against cervical cancer (HPV - Human Papillomavirus) was documented. The outstanding efficacy was demonstrated as success was seen not only in the treatment of patients with existing tumors but also in preventive vaccinations against cervical cancer. That is a critical win, as only preventive vaccines have existed on the market to date.

    According to experts, the market for cervical cancer drugs is expected to grow to nearly USD 13 billion by 2028. Thus, the Canadians are on an exciting and extremely lucrative path. Given the potential, the market capitalization of around CAD 260 million can be considered moderate.

    Bayer - Positive analyst opinion

    Even though the problem child "glyphosate" is once again attracting more media attention, there has also recently been positive newsflow at the German life science company. The glyphosate weedkiller, which Bayer acquired during the takeover of the US company Monsanto a few years ago, led to waves of lawsuits for causing cancer and resulted in claims for damages worth billions.

    Recently, a positive commentary by Citigroup on the drug candidate Asundexian boosted the share. The experts raised their price target from EUR 102 to EUR 106, which corresponds to an upside potential of almost 40%. The analysts believe that the anticoagulant will generate peak annual sales of more than USD 6 billion. Bayer had published positive data for the drug 2 months ago. Asundexian is seen as a potential successor to the blockbuster Xarelto.

    Uncertainty still prevails at Valneva. If, after the UK, the EU now also gives the green light for approval of the Corona vaccine, the stock has the potential to catch up. Bayer is a fundamental investment in the life science sector, which analysts consider undervalued. Defence Therapeutics is on a very good path to launching a blockbuster in the field of cervical cancer in the next few years, making the stock the most promising of the trio.

    Conflict of interest

    Pursuant to §85 of the German Securities Trading Act (WpHG), we point out that Apaton Finance GmbH as well as partners, authors or employees of Apaton Finance GmbH (hereinafter referred to as "Relevant Persons") may hold shares or other financial instruments of the aforementioned companies in the future or may bet on rising or falling prices and thus a conflict of interest may arise in the future. The Relevant Persons reserve the right to buy or sell shares or other financial instruments of the Company at any time (hereinafter each a "Transaction"). Transactions may, under certain circumstances, influence the respective price of the shares or other financial instruments of the Company.

    In addition, Apaton Finance GmbH is active in the context of the preparation and publication of the reporting in paid contractual relationships.

    For this reason, there is a concrete conflict of interest.

    The above information on existing conflicts of interest applies to all types and forms of publication used by Apaton Finance GmbH for publications on companies.

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    Der Autor

    Carsten Mainitz

    The native Rhineland-Palatinate has been a passionate market participant for more than 25 years. After studying business administration in Mannheim, he worked as a journalist, in equity sales and many years in equity research.

    About the author

    Related comments:

    Commented by Fabian Lorenz on May 16th, 2024 | 08:00 CEST

    Share price shock at Siemens Energy! What are BioNTech and Cardiol Therapeutics doing?

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    The Siemens Energy share has been one of the surprises of recent months. It has more than doubled since the beginning of the year. Is a crash now imminent? Yes, if you believe Bernstein. Their analysts are shocking us with a horror price target. The Cardiol Therapeutics share performed even better than Siemens Energy in 2024. Despite the 150% rally, analysts see upside potential for the cardiovascular disease specialist. Things will get really exciting at the beginning of June when new study results are due. BioNTech, on the other hand, is currently failing to convince analysts. Reactions to the latest quarterly figures were modest.


    Commented by Stefan Feulner on May 14th, 2024 | 07:30 CEST

    Bayer, Defence Therapeutics, Novavax - Major events

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    The biotechnology sector is still on the move and is currently characterized by a high degree of volatility. For instance, BioNTech, a former star during the pandemic, reported a net loss of EUR 315 million in the first quarter. The Mainz-based biotech now wants to focus more on the development of its cancer drugs due to the slump in demand for COVID-19 vaccines. However, for years, innovative, undiscovered companies have existed in this billion-dollar market that could, with their technologies, become the new high-flyers in the biotech industry.


    Commented by André Will-Laudien on May 9th, 2024 | 07:00 CEST

    Biotech and pharma stocks finally follow suit! Novo Nordisk, Bayer, BioNTech, Vidac Pharma and Evotec on the buy list

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    Things looked very different at the beginning of the year. After a brilliant rally in the Nasdaq Biotech Index at the end of last year, investors thought the upswing could continue in 2024. So far, this hope has not been confirmed. The main focus for the industry is the refinancing conditions. These have gradually deteriorated, as stubborn inflation is keeping central bank interest rates high. And judging by the wording of central bankers, the next interest rate cut does not seem to be penciled in yet. However, if it happens in the summer, things will likely move quickly for the life sciences sector. Then a quick sector rotation is the order of the day! Here is our buy list for the upcoming event.