November 3rd, 2021 | 10:16 CET
Valneva, Cardiol Therapeutics, BioNTech - Is the vaccination subscription coming?
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"[...] As a company dedicated to developing treatments for rare heart diseases, we see this as an opportune moment to contribute to the fight against heart disease and make meaningful strides in improving heart health worldwide. [...]" David Elsley, CEO, Cardiol Therapeutics Inc.
Valneva - Waiting for the substance
The discussions about the various types of vaccines are endless. Besides the mRNA vaccines from BioNTech and Moderna, vector vaccines like AstraZeneca have been administered. Vaccination skeptics have criticized the mRNA vaccine in particular. Because of the accusation that it affects our genetic material, they have so far stayed away from protection against the coronavirus and are waiting for the first inactivated vaccine, which the Austrian-French Company Valneva wants to bring to approval.
Inactivated vaccines contain killed pathogens, i.e. pathogens that cannot reproduce or only their components. These are recognized by the body as foreign and stimulate the body's defense system to produce antibodies without the respective disease breaking out.
With a successfully completed capital increase and gross proceeds of approximately EUR 88.00 million, Valneva's vaccine projects are to be accelerated. The project pipeline is bulging. In addition to the COVID-19 vaccine VLA2001, additional money must be invested in the Chikungunya vaccine candidate VLA1553 and VLA15 for protection against Lyme disease. Studies to date show the potential of the inactivated vaccine. VLA2001 has achieved a higher level of antibodies with fewer side effects compared with the AstraZeneca vaccine in about 4,000 subjects over the age of 18, the Company said.
Cardiol Therapeutics - Blockbuster for the heart
An infection with the SARS-CoV-2 coronavirus can also attack the heart, and in some cases, possibly lead to myocarditis. Recently, it has also been discussed that inflammation of the heart muscle, and in some cases also of the pericardium, occurs in a few patients following the Covid-19 vaccination, especially with a so-called mRNA vaccine.
Cardiol Therapeutics, a Canadian biotechnology company listed on Nasdaq, focuses on producing pharmaceutical cannabidiol (CBD) products and the development of innovative therapies for heart disease, including acute myocarditis and other causes of heart failure. Cardiol's lead product, CardiolRX, a highly purified and concentrated oral cannabidiol formulation, is the focus of this effort and is currently being evaluated in a Phase II/III outcomes study.
The Company received positive news from Health Canada, which granted approval to continue work on the multicenter, double-blind, randomized, placebo-controlled Phase II study designed to evaluate the safety and tolerability of CardiolRx and its effects on myocardial regeneration in patients with acute myocarditis. The study is expected to enroll 100 patients in clinical centers in the United States, Canada and Europe.
Cardiovascular disease is the leading cause of death in the Western world, independent of SARS-CoV-2. Cardiol Therapeutics has successfully progressed through the phases to date and continues to have tremendous potential in a multi-billion dollar market.
BioNTech - In the wake of the partner
The share price of the Mainz-based biotech Company benefited from the third quarter figures of its partner Pfizer, which exploded due to the joint preparation Comirnaty. Sales increased by 130% to USD 24.1 billion. The main sales driver was the jointly developed compound.
If Comirnaty is excluded from the figures, revenue growth of only 7% to USD 11.1 billion remains. BioNTech itself will publish its 9-month figures on November 9.
The share price reaction shows investors' expectations with a 3% gain to EUR 282.20. Above the level of around EUR 285.00, there should be a renewed attack on the October high at EUR 304.00.
Infection figures are rising rapidly again, but the pace of vaccination is slowing. To achieve better protection against the virus, "booster" vaccinations for all are currently being discussed, which will, of course, give the already approved vaccines such as Comirnaty a further boost in sales. BioNTech is promising, while we should wait and see with Valneva. Cardiol Therapeutics also has enormous potential with its preparation against heart disease.
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