Close menu

September 23rd, 2022 | 11:28 CEST

Defence Therapeutics, Amazon, BioNTech - Innovative technologies for health

  • Biotechnology
  • Investments
  • Healthcare
Photo credits:

While WHO Director-General Tedros Adhanom Ghebreyesus sees the end of the Corona pandemic within reach, companies like BioNTech have more products in the pipeline to bring successful drugs to market. In order to ensure that this happens thoroughly and more quickly, Canadian company Defence Therapeutics is stepping up to shorten development cycles with a unique platform technology in oncology. Cancer has still not been eradicated. An end, however, is in sight for Amazon's in-house healthcare division. Amazon Care is closing its doors at the end of the year, but the Seattle-based corporation still cannot let go of the lucrative healthcare business...

time to read: 5 minutes | Author: Juliane Zielonka

Table of contents:

    David Elsley, CEO, Cardiol Therapeutics Inc.
    "[...] As a company dedicated to developing treatments for rare heart diseases, we see this as an opportune moment to contribute to the fight against heart disease and make meaningful strides in improving heart health worldwide. [...]" David Elsley, CEO, Cardiol Therapeutics Inc.

    Full interview


    Defence Therapeutics - Platform technology in the fight against cancer

    Pharmaceutical industry insiders know that the shorter the development cycles for new drugs become, the faster there is revenue-generating growth potential through sales. It takes an average of 13 years to develop a drug. The average cost of developing a new innovative drug is up to EUR 2.6 billion. Especially in cancer treatment, it can therefore be too late for many patients until a new drug to relieve their symptoms receives its approval.

    In order to shorten this development time without compromising quality, the Canadian biotech company Defence Therapeutics offers an innovative platform technology specifically for oncology. "Accum" is the name of the platform that helps improve biologic drugs. It is used in the treatment of cancer and infectious diseases.

    Defence Therapeutics focuses on specialized cell nucleus research to solve a major problem in vaccines and antibody-drug conjugates (ADCs). When a target cell binds and internalizes an antigen or ADC, the complex becomes entrapped in small vesicles called endosomes. These endosomes eventually undergo a maturation phase until degradation. The entrapment of endosome lysosomes is often problematic and severely limits the efficacy of these types of therapies.

    Defence Therapeutics' Accum-Enhancer formulation improves intracellular delivery of biological therapeutics by bundling the process to increase therapeutic efficacy. Defence Therapeutics owns all rights and patents to the proprietary platform solution. Its unique technology can thus accelerate drug development against breast cancer, colorectal cancer, lymphoma and skin cancer (melanoma). The stock currently stands at EUR 1.24, analysts at Barron's issue a buy recommendation.

    Amazon - In-house care division closes down

    One of the world's largest and most successful platform technology operators is still Amazon. Also in Seattle, Amazon is trying its hand at the lucrative health sector. Just recently, Amazon talked about taking over the US telemedicine provider One Medical from San Francisco for USD 3.9 billion. One Medical operates 182 GP practices. Users can book virtual or in-person doctor treatments around the clock for a fee. One Medical also works with over 8,000 businesses whose employees can use the physician network. At the moment, the deal is under regulatory scrutiny.

    On the other hand, Amazon has closed its own Care division. Amazon Care, a telehealth startup from Amazon, was designed to help patients. According to ratings, reviews and patient interviews, the project has been a great success. However, that does not seem to be the case for the startup's actual customers - businesses. In an email to his staff, Neil Lindsay, Senior Vice President of Amazon Health, said that Amazon Care "is not a complete enough offering for the large enterprise customers we have been targeting".

    By the end of 2022, all ambitions to run its own patient record and physician service will expire. How does that fit together? In a memo to employees announcing the closure of Amazon Care, their executive indicated that the Company had not satisfied its enterprise customers That could also be related to the tech giant's fast-paced, frugal approach to health care - an approach that former employees had previously criticized. Medical professionals hired to provide care were reported to sometimes have conflicts with the Company because of that approach, according to an Amazon spokesperson, who says the Company will "continue to work with industry stakeholders as part of this transition" even after Amazon Care closes.

    In healthcare, there is no shortcut to sequential steps, only a way to shorten the timeframes of each step, as Defence Therapeutics is doing.

    BioNTech - Israel launches vaccine with adapted Omicron compound

    With a presumed 329.5 million vaccine candidates down, the BioNTech share slides 8.6% this week. US President Joe Biden unceremoniously declared the Corona pandemic over. Health officials continue to view the current pandemic as a serious public health threat. Thousands of people are newly infected with the virus every day, which could lead to an increase in the number of infections in the coming fall and winter months.

    On Thursday, Israel started the vaccination campaign against the Omicron variant of the coronavirus. The vaccine doses from BioNTech and Pfizer are specifically tailored to the mutant variant, which has recently been very common in Israel. Israel led the world in vaccinating its 9.5 million residents against coronavirus last year. In a very short period of time, more than 60% of the population had been vaccinated with at least two doses of the Pfizer/BioNTech vaccine by the fall. More than 4.5 million Israelis have received a third dose of the vaccine, but only slightly more than 800,000 have received the fourth and final vaccination to date.

    Whether demand will increase with the adjusted vaccine remains in question. Israel has always taken a lead role as a nation in the fight against the coronavirus. While the World Health Organization has still classified COVID-19 as a pandemic, the end of the crisis appears to be in sight. Director-General Tedros Adhanom Ghebreyesus made the announcement last week. BioNTech has other drugs in the pipeline that will be used in the fight against cancer, among other things.

    Size and money are not decisive criteria for success in the healthcare industry. It requires relevant experience and expertise to understand and improve the complex interrelationships. Defence Therapeutics is an expert company. The team has deep experience in oncology and is well versed in drug development cycles. Those interested in learning more can ask Dr Moutih Rafei, Vice President R&D, questions at the Virtual II Forum on September 27. Click here to register for free. The proprietary platform solution enables the Company to shorten production runs without sacrificing quality, especially in oncology. Cancer is another milestone for BioNTech. In the pipeline lie products in the fight against prostate cancer, skin cancer and malignant ovarian cancer. Now that the Corona pandemic is coming to an end, the Company should be on the starting blocks with new diversified drugs. US platform giant Amazon, on the other hand, still seems to be searching for the golden nugget in the healthcare industry. Although its own service Amazon Care is closing, there is still interest in acquiring telemedicine provider One Medical.

    Conflict of interest

    Pursuant to §85 of the German Securities Trading Act (WpHG), we point out that Apaton Finance GmbH as well as partners, authors or employees of Apaton Finance GmbH (hereinafter referred to as "Relevant Persons") may hold shares or other financial instruments of the aforementioned companies in the future or may bet on rising or falling prices and thus a conflict of interest may arise in the future. The Relevant Persons reserve the right to buy or sell shares or other financial instruments of the Company at any time (hereinafter each a "Transaction"). Transactions may, under certain circumstances, influence the respective price of the shares or other financial instruments of the Company.

    In addition, Apaton Finance GmbH is active in the context of the preparation and publication of the reporting in paid contractual relationships.

    For this reason, there is a concrete conflict of interest.

    The above information on existing conflicts of interest applies to all types and forms of publication used by Apaton Finance GmbH for publications on companies.

    Risk notice

    Apaton Finance GmbH offers editors, agencies and companies the opportunity to publish commentaries, interviews, summaries, news and the like on These contents are exclusively for the information of the readers and do not represent any call to action or recommendations, neither explicitly nor implicitly they are to be understood as an assurance of possible price developments. The contents do not replace individual expert investment advice and do not constitute an offer to sell the discussed share(s) or other financial instruments, nor an invitation to buy or sell such.

    The content is expressly not a financial analysis, but a journalistic or advertising text. Readers or users who make investment decisions or carry out transactions on the basis of the information provided here do so entirely at their own risk. No contractual relationship is established between Apaton Finance GmbH and its readers or the users of its offers, as our information only refers to the company and not to the investment decision of the reader or user.

    The acquisition of financial instruments involves high risks, which can lead to the total loss of the invested capital. The information published by Apaton Finance GmbH and its authors is based on careful research. Nevertheless, no liability is assumed for financial losses or a content-related guarantee for the topicality, correctness, appropriateness and completeness of the content provided here. Please also note our Terms of use.

    Der Autor

    Juliane Zielonka

    Born in Bielefeld, she studied German, English and psychology. The emergence of the Internet in the early '90s led her from university to training in graphic design and marketing communications. After years of agency work in corporate branding, she switched to publishing and learned her editorial craft at Hubert Burda Media.

    About the author

    Related comments:

    Commented by Stefan Feulner on July 17th, 2024 | 06:30 CEST

    BioNTech, Cardiol Therapeutics, Bayer - Prepared for the next wave

    • Biotechnology
    • Biotech
    • Pharma

    The assassination attempt on former and possibly future US President Donald Trump was clearly the dominant topic at the weekend, causing both gold and the largest cryptocurrencies to surge at the start of the week. Still largely unnoticed, however, the COVID-19 figures are rising again, especially in the United States, which could halt the downward spiral for vaccine manufacturers such as BioNTech/Pfizer and Moderna.


    Commented by Fabian Lorenz on July 11th, 2024 | 06:55 CEST

    Shares with breakthrough potential? Evotec, Varta, and Carbon Done Right Developments

    • Sustainability
    • Pharma
    • Biotechnology
    • renewableenergies
    • CarbonCredits

    Evotec is currently going from strength to strength. Yesterday, a partnership with pharmaceutical giant Pfizer boosted the share price. Will the resistance at EUR 10 now finally fall? There has also been positive news for Varta recently. Is the possible collaboration with Porsche a game changer? Analysts have a clear opinion on this matter. At Carbon Done Right Developments, investors are eagerly awaiting the AIM listing. Once it happens, the share price could explode, as the Company is working on an ecosystem within a billion-dollar market. Should you position yourself now? In any case, all three companies are working towards a breakthrough.


    Commented by André Will-Laudien on July 11th, 2024 | 06:45 CEST

    Mega rally on the cards - 500% plus is likely too low an estimate! Evotec, Desert Gold, Cogia, VCI Global, and Lufthansa

    • Mining
    • Gold
    • Commodities
    • Biotechnology
    • airline

    The stock market keeps rising and rising - this much is revealed by the ever-new highs of prominent indices such as the NASDAQ 100, S&P 500, or the Nikkei index. However, a closer look reveals some inconsistencies. For example, only 6% of all traded stocks are currently reaching new highs, while over 70% of all listed stocks have fallen since the beginning of the year. In short, global liquidity is aggregated in just a few blockbuster stocks, with the rest being left behind. Such bubbles already occurred in 1999, 2007, and 2015, followed by a 25% to 50% correction. When exactly this will happen, no one knows, but the party is likely to continue for a while due to high liquidity. Gold and silver are in the process of forming interesting breakout formations. Now is the time to pick the cherries!