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December 3rd, 2021 | 12:38 CET

BioNTech, Defence Therapeutics, QIAGEN - End in sight?

  • Biotechnology
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The federal and state governments have met and decided on a de facto lockdown for the unvaccinated. In the future, only vaccinated and recovered people will be allowed to shop in retail stores. The same applies to cinemas, theaters and restaurants. In addition, the unvaccinated will have to accept contact restrictions. According to the outgoing chancellor, this is an "act of national solidarity" and is necessary to get out of the current difficult situation - hard times, which the Omicron variant has just exacerbated. But according to US strategists, it is precisely the newly emerged mutant that could signal the approaching end of the Corona pandemic.

time to read: 4 minutes | Author: Stefan Feulner

Table of contents:

    David Elsley, CEO, Cardiol Therapeutics Inc.
    "[...] As a company dedicated to developing treatments for rare heart diseases, we see this as an opportune moment to contribute to the fight against heart disease and make meaningful strides in improving heart health worldwide. [...]" David Elsley, CEO, Cardiol Therapeutics Inc.

    Full interview


    BioNTech - New target group

    According to Bloomberg, JP Morgan market strategists Marko Kolanovic and Brian Kaplan write in a published study that "Omicron could signal that the end of the pandemic is in sight." The experts base their thoroughly surprising thesis on historical patterns of virus development. Citing scientists, the strategists write that while the Omicron variant is more contagious, it causes less severe disease. If confirmed, "the Omicron variant could ultimately prove positive for risk markets, in the sense of hastening the end of the pandemic." The pandemic could then potentially change to make Corona "more like the seasonal flu," the authors said. Such a development would be consistent with historical patterns of previous viral pandemics.

    In contrast, Ugur Sahin, CEO of vaccine manufacturer BioNTech, sees a "tough four to five months" ahead for society. In addition to patience, he said, vaccinations are essential to defeating the fourth wave. In the process, a new target group has been tapped, children in the 5 to 11 age group. Even one week earlier than planned, on December 13, the first tranche of 2.4 million doses is to be delivered to Germany. We are talking about up to 13 million doses of the pediatric vaccine for the EU before the end of 2021.

    Defence Therapeutics - Visionary platform

    In contrast to BioNTech, with a market capitalization of USD 66.37 billion, Defence Therapeutics, with a stock market value of EUR 132.99 million, is still in the early stages of development. The Canadians are working to develop the next generation of vaccines and ADC products with their proprietary platform. At the core of the Defence Therapeutics platform is ACCUM technology, which enables precise transport of vaccine antigens or ADCs in the intact form to target cells. As a result, improved efficiency and efficacy against many diseases such as cancer and infections can be achieved. Having filed four new patents last year, the technologies of Defence have an increasing portfolio of intellectual property rights.

    In this context, the technology can be applied with particular precision in vaccine development. Research activities conducted by the Company have identified that adding Accum-bound antigens to allogeneic DCs (AccuVAC-D001) increases the therapeutic effect of the vaccine and achieves a survival rate of 70-80%, compared to the 0-20% achieved by current experimentally proven DC-based vaccines. After completing this study, Defence Therapeutics has signed an agreement with a cleanroom provider in Canada to conduct trial runs with its DC vaccine. The goal is to complete all required GLP studies by the first quarter of 2022 and to complete a Phase I trial against melanoma in the UK by mid-2022.

    In addition, all preclinical activities related to its COVID-19 vaccines have already been completed. The data obtained achieved high reactivity against all variants tested. The second vaccine formulation (DTC-IN003) is a vaccine that blocks transmission to stop infection. Also in development is a vaccine against human papillomavirus (HPV). The effect of the AccuVAC-PT009 vaccine is being compared to the commercially available Gardasil-9 vaccine in terms of immunogenicity. In addition, Defence is working on a second HPV-related vaccine that will specifically target cervical cancer.

    Through the Accum technology platform, the fields of application seem endless. However, it should not be forgotten that the Company is still in the early stages of development. Due to this, an entry at this early stage is extremely risky, but the opportunities are enormous if the innovative platform continues to develop positively.

    QIAGEN - A model of a good start

    The share of the provider of sample preparation and testing technologies for molecular diagnostics, academic research and the pharmaceutical industry has made a model run at the resistance level of EUR 48.00. A successful test should lift the share back towards the old high for the year at EUR 51.40.

    On the news side, the Company announced the CE mark of its QuantiFERON SARS-CoV-2 test, which can detect T-cell response to SARS-CoV-2 and determine immunity status following COVID-19 vaccination. The QuantiFERON SARS-CoV-2 assay is based on QIAGEN's QuantiFERON IGRA (Interferon-Gamma Release Assay) technology, recognized worldwide as an easy-to-use assay. Unlike other T-cell tests, the assay uses whole blood and does not require the purification of lymphocytes prior to T-cell detection.

    "T cells provide us with valuable insights into the immune response to COVID-19," said Jean-Pascal Viola, senior vice president and head of QIAGEN's Molecular Diagnostics business unit. "The better we understand this pandemic, the more likely we are to be able to deal with this threat worldwide, which will continue to be with us. We are excited to make a new contribution to measuring the immune response with QuantiFERON technology, which is essential for disease prevention and management."

    It is decided. The unvaccinated are marching into a de facto lockdown. In contrast, experts at JP Morgan see Omicron as a signal that the pandemic is weakening. According to policymakers and industry, the main tool continues to be vaccination and testing. BioNTech is the leader in this area, and Defence Therapeutics has enormous development potential with its platform. QIAGEN is interesting from a technical perspective.

    Conflict of interest

    Pursuant to §85 of the German Securities Trading Act (WpHG), we point out that Apaton Finance GmbH as well as partners, authors or employees of Apaton Finance GmbH (hereinafter referred to as "Relevant Persons") may in the future hold shares or other financial instruments of the mentioned companies or will bet on rising or falling on rising or falling prices and therefore a conflict of interest may arise in the future. conflict of interest may arise in the future. The Relevant Persons reserve the shares or other financial instruments of the company at any time (hereinafter referred to as the company at any time (hereinafter referred to as a "Transaction"). "Transaction"). Transactions may under certain circumstances influence the respective price of the shares or other financial instruments of the of the Company.

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    Der Autor

    Stefan Feulner

    The native Franconian has more than 20 years of stock exchange experience and a broadly diversified network.
    He is passionate about analyzing a wide variety of business models and investigating new trends.

    About the author

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