Close menu




December 30th, 2022 | 17:52 CET

BioNTech, Defence Therapeutics, Pfizer - The cards are being reshuffled

  • Biotechnology
  • Covid19
  • Investments
Photo credits: pixabay.com

The Corona pandemic is seemingly coming to an end after almost three long years. The return to normality, now in China and the rest of the world, is a relief for society and the economy. In contrast, vaccine manufacturers are losing a billion-dollar business that is difficult to compensate for with products in other areas of application. Nevertheless, the stock market valuations of the vaccine producers continue to be exorbitantly high, as does their drop in value.

time to read: 4 minutes | Author: Stefan Feulner
ISIN: BIONTECH SE SPON. ADRS 1 | US09075V1026 , DEFENCE THERAPEUTICS INC | CA24463V1013 , PFIZER INC. DL-_05 | US7170811035

Table of contents:


    David Elsley, CEO, Cardiol Therapeutics Inc.
    "[...] As a company dedicated to developing treatments for rare heart diseases, we see this as an opportune moment to contribute to the fight against heart disease and make meaningful strides in improving heart health worldwide. [...]" David Elsley, CEO, Cardiol Therapeutics Inc.

    Full interview

     

    Single-product company seeks alternatives

    The abrupt end of the "Zero-COVID policy" in China caused a sigh of relief around the globe last week. The return to normality should now be set. Even the well-known and previously very cautious virologist Christian Drosten considers the Corona pandemic in Germany to be over. This winter was the first endemic wave, he told "Tagesspiegel". Justice Minister Bushman also calls for the end of all Corona measures as a consequence.

    The announcement of the end of the pandemic is likely to have put global vaccine manufacturers on high alert, especially if, as is the case with BioNTech, the Corona vaccines are the only products marketable to date, which, looking at the product pipeline, is unlikely to change in the near future. Although the Mainz-based company repeatedly emphasizes that it is driving forward the field of oncology based on mRNA technology, experience has shown that it will probably be years before actual approval is granted.

    In addition, BioNTech and its US partner Pfizer have developed a combination vaccine that could be used in the future to vaccinate against Corona and influenza at the same time. This has been included in an accelerated approval process by the US Food and Drug Administration (FDA). Whether this vaccine will be well received once approved is questionable. Currently, BioNTech's market capitalization is USD 36.82 billion, despite correction. As of September 30, 2022, the Company had high liquidity of EUR 13.4 billion and trade receivables of EUR 7.3 billion. For the full year 2022, the Mainz-based company still expects between EUR 16 and 17 billion in sales. For 2023, the decline in sales and earnings is likely to be drastic, should the Corona pandemic be over.

    From a chart perspective, the situation does not look any better. After bouncing off the high for the year at USD 188.82, the share fell back into its broad sideways channel with high volumes, which marks the low for the year at USD 117.48 as the lower edge. RSI and MACD gave a fresh sell signal on a weekly basis, so a further slide into this region or below appears likely.

    Completely new possibilities against cancer

    Compared to BioNTech, the Canadian biotech company Defence Therapeutics, with a market capitalization of USD 69.71 million, is far from exaggerated. That is because the Canadians' highly scalable platform technology has the potential to develop the next generation of vaccines and ADC products. At the core of the Defence Therapeutics platform is ACCUM technology, which enables the precise transport of vaccine antigens or ADCs in the intact form to target cells. As a result, improved efficiency and efficacy against serious diseases such as cancer and infectious diseases can be achieved.

    Currently, Defence Therapeutics is working on combining its ACCUM technology with mRNA vaccines. This research program will not only impact the field of cancer immunotherapy but can also be directly applied to developing new vaccines against infectious diseases. For example, the Canadians have demonstrated that while "pure" mRNA can indeed be immunogenic, the humoral antibody response generated against the vaccine is very weak. The Defence team is therefore working with a private European company to synthesize mRNA vaccines in conjunction with ACCUM. The goal is to directly compare ACCUM-linked and "pure" mRNA vaccines in terms of their potential to generate an immune response that can eradicate and control existing tumors. According to Defence Therapeutics CEO Sebastien Plouffe, the ACCUM mRNA vaccine is expected to be in production by the end of 2023. After that, in vivo studies will be initiated in animals with existing solid tumors. "Once completed, Defence will have its 100% proprietary ACCUM-linked cancer mRNA vaccine. Defence will also be able to license its customized ACCUM technology to any pharmaceutical company with mRNA vaccines," he added.

    Groundbreaking results

    Also groundbreaking were the results of a preclinical study using the intranasal formulation of AccuTOX in the context of animals with existing lung cancer. The study showed that administration of AccuTOX as a combination therapy with the immune checkpoint inhibitor PD-1 antibody dramatically reduced the number of lung nodules compared to animals in the untreated or PD-1 antibody-treated control group. This 50% reduction in cancer nodules in animals with existing lung tumors was achieved with a treatment schedule of just 6 doses administered over a 2-week period with the combination of AccuTOX and PD-1 antibodies. Defence is currently preparing its meeting with the US Food and Drug Administration (FDA) to seek approval to initiate a Phase I trial for the treatment against solid tumors in 2023. According to Precedence Research, the global lung cancer therapeutics market was valued at approximately USD 27.57 billion in 2021 and is expected to grow to USD 55.6 billion by 2030.


    The Corona pandemic is coming to an end in leaps and bounds, which means an end to the special boom for vaccine manufacturers like BioNTech. With only one product established in the market, the Company's forecasts for 2023 are likely to be somewhat sobering. In comparison, Defence Therapeutics has enormous growth potential with its highly scalable platform technology.


    Conflict of interest

    Pursuant to §85 of the German Securities Trading Act (WpHG), we point out that Apaton Finance GmbH as well as partners, authors or employees of Apaton Finance GmbH (hereinafter referred to as "Relevant Persons") may hold shares or other financial instruments of the aforementioned companies in the future or may bet on rising or falling prices and thus a conflict of interest may arise in the future. The Relevant Persons reserve the right to buy or sell shares or other financial instruments of the Company at any time (hereinafter each a "Transaction"). Transactions may, under certain circumstances, influence the respective price of the shares or other financial instruments of the Company.

    In addition, Apaton Finance GmbH is active in the context of the preparation and publication of the reporting in paid contractual relationships.

    For this reason, there is a concrete conflict of interest.

    The above information on existing conflicts of interest applies to all types and forms of publication used by Apaton Finance GmbH for publications on companies.

    Risk notice

    Apaton Finance GmbH offers editors, agencies and companies the opportunity to publish commentaries, interviews, summaries, news and the like on news.financial. These contents are exclusively for the information of the readers and do not represent any call to action or recommendations, neither explicitly nor implicitly they are to be understood as an assurance of possible price developments. The contents do not replace individual expert investment advice and do not constitute an offer to sell the discussed share(s) or other financial instruments, nor an invitation to buy or sell such.

    The content is expressly not a financial analysis, but a journalistic or advertising text. Readers or users who make investment decisions or carry out transactions on the basis of the information provided here do so entirely at their own risk. No contractual relationship is established between Apaton Finance GmbH and its readers or the users of its offers, as our information only refers to the company and not to the investment decision of the reader or user.

    The acquisition of financial instruments involves high risks, which can lead to the total loss of the invested capital. The information published by Apaton Finance GmbH and its authors is based on careful research. Nevertheless, no liability is assumed for financial losses or a content-related guarantee for the topicality, correctness, appropriateness and completeness of the content provided here. Please also note our Terms of use.


    Der Autor

    Stefan Feulner

    The native Franconian has more than 20 years of stock exchange experience and a broadly diversified network.
    He is passionate about analyzing a wide variety of business models and investigating new trends.

    About the author



    Related comments:

    Commented by Nico Popp on October 1st, 2025 | 07:15 CEST

    The stock for the Dubai boom: Emirates NBD, Finexity, eToro

    • Tokenization
    • Investments
    • Banking
    • Digitization
    • Trading

    Dubai is increasingly establishing itself as a global hub for financial innovation. The city combines growth-oriented policies with open regulatory conditions, allowing foreigners to purchase real estate, for example. At the same time, Dubai is promoting blockchain and the tokenization of assets. In 2021, the Dubai Land Authority launched a pilot project for blockchain-based real estate tokenization to enable fractional ownership and give international investors access to this asset class. In this article, we explain the business models surrounding Dubai, tokens, and the future of investing, and why a company from Hamburg is causing a stir.

    Read

    Commented by Carsten Mainitz on September 30th, 2025 | 07:40 CEST

    Antimony Resources, Rheinmetall, Novo Nordisk – Something is in the air!

    • Mining
    • antimony
    • Defense
    • Biotechnology

    Sufficient access to raw materials is crucial for any economy. The EU has compiled a list of 34 critical raw materials. How critical a raw material is classified depends on two parameters: "economic importance" and "supply risk." This list also includes a little-known but very important metalloid – antimony. The price of antimony skyrocketed at the end of 2024 in the wake of China's export ban. There are still exciting investment opportunities in this area.

    Read

    Commented by André Will-Laudien on September 30th, 2025 | 07:35 CEST

    High-tech super boom! 1,000% no problem—here is more from D-Wave, NetraMark and Palantir!

    • Biotechnology
    • AI
    • Digitization
    • hightech
    • computing
    • Software

    Artificial intelligence (AI) is currently revolutionizing drug development by analyzing enormous amounts of data in a very short time and making clinical trials much more targeted. Modern AI systems make it possible to select drug candidates with precision and predict the potential success of a therapy with a high degree of accuracy. Companies like NetraMark are already using these technologies profitably. Players such as D-Wave and Palantir are also among the pioneers of the new AI-driven economy and have seen their share prices rise by over 1,000%. Expectations for further growth are virtually limitless. The advent of quantum computer technology also marks the beginning of a new chapter in ultra-fast data processing. For forward-looking investors, this opens up attractive entry opportunities in dynamically expanding future markets. Those who bet on the right players early on can benefit from this change to an above-average extent.

    Read