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February 8th, 2023 | 11:49 CET

BioNTech, Pfizer, Cardiol Therapeutics, Bayer - Biotech stocks facing a revival?

  • Biotechnology
  • Cancer
  • vaccine
  • Cannabis
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The BIO Deutschland association represents the German biotech industry. According to an announcement on January 18, financing of biotech companies plummeted by 2/3 in 2022. Overall, the sector raised only EUR 920 million in equity. During the Corona pandemic, many biotech stocks did well. Subsequently, profit-taking occurred and rising interest rates put additional pressure on stocks. That could change in 2023. Meanwhile, some companies are valued low, and so these companies appear on the radar of investors from the United States. According to Handelsblatt, Water Street, an investment company focused on pharma and biotech, has already invested EUR 1 billion, mainly in Germany. A total of EUR 6 billion is to be invested.

time to read: 4 minutes | Author: Armin Schulz
ISIN: BIONTECH SE SPON. ADRS 1 | US09075V1026 , PFIZER INC. DL-_05 | US7170811035 , CARDIOL THERAPEUTICS | CA14161Y2006 , BAYER AG NA O.N. | DE000BAY0017

Table of contents:

    David Elsley, CEO, Cardiol Therapeutics Inc.
    "[...] As a company dedicated to developing treatments for rare heart diseases, we see this as an opportune moment to contribute to the fight against heart disease and make meaningful strides in improving heart health worldwide. [...]" David Elsley, CEO, Cardiol Therapeutics Inc.

    Full interview


    BioNTech - Pfizer with sales problems in Q4

    While the World Health Organization continues to consider COVID-19 a public health emergency, the Biden administration announced the expiration of the public health emergency on May 11. As a result, the contracts are no longer in effect, and prices for Corona vaccines are expected to rise significantly. On the other hand, demand for the vaccines will also drop significantly. This is not good news for market leader BioNTech, whose shares have lost more than EUR 45 in value since mid-December.

    BioNTech's partner Pfizer has already presented its figures for the 4th quarter. Already there, it shows a decline in sales of the Comirnaty vaccine. Year-on-year, sales fell by 9% to around USD 11.3 billion. There was a slight increase of 3% for the full year, with sales of USD 37.8 billion. Pfizer's assessment of the current year is significantly worse. In its forecasts, it expects annual sales of USD 13.5 billion. That is a drop of more than 60%. BioNTech is scheduled to present its figures on February 20. It is safe to assume that the numbers will look similar to Pfizer's.

    As a result, profits are shrinking, but the Mainz-based company has raised so much money in recent years that research and development will be covered for years to come. The product pipeline is fully focused on the area of oncology. To speed up research, the Company plans to relocate to the UK. Only with a new blockbuster are the old highs likely to be reached. Until then, investors will have to be patient. The share is currently trading at EUR 131.10 and has thus fallen back into the September / October 2022 range.

    Cardiol Therapeutics - First patient in Phase II study

    The number of cardiovascular diseases has been growing for years, and this trend will continue due to higher life expectancy. Cardiol Therapeutics is a clinical-stage biotechnology company focused on this growing market with the development of anti-inflammatory and anti-fibrotic therapies for heart disease. Its lead product candidate, CardiolRx, is a pharmaceutically manufactured oral solution containing cannabidiol for treating heart disease. The Company has received approval from the FDA to conduct Phase II clinical trials to treat acute myocarditis and recurrent pericarditis. In parallel with the trials, the Company is also developing a subcutaneously administered cannabidiol-based drug formulation to treat heart failure.

    On January 17, Cardiol was pleased to announce that the first patient has been enrolled in the open-label Phase II pilot study evaluating the safety, tolerability and efficacy of CardiolRx in treating recurrent pericarditis. The study will also evaluate improvement in objective measures of disease and assess the feasibility of discontinuing background therapy, including corticosteroids, while taking CardiolRx. Approximately 25 patients will be enrolled in the study at specialized centers in the United States. Cleveland Clinic cardiologist Dr Paul C. Cremer said, "We are pleased to be the first clinical center to use this investigational drug in a patient with recurrent pericarditis, a debilitating inflammatory heart disease associated with symptoms that affect the quality of life and physical activity."

    Phase II studies are expected to be completed in the next 12-24 months. As of September 30, 2022, CAD 65.5 million remained in cash, which should fund the Company through 2026. Those looking for more in-depth information on the Company should visit Alternatively, CEO David Elsley is presenting the Company at the 6th International Investment Forum on February 15, where interested parties can also ask questions live. After the share price rose from USD 0.51 at the beginning of the year to almost USD 0.81 on the NASDAQ, the stock is currently consolidating. Currently, one pays USD 0.6644 for a share certificate.

    Bayer - Pharmaceuticals business is developing well

    The Monsanto takeover continues to weigh on the Group. The Crop Science division, which is benefiting from the current situation surrounding the Ukraine conflict, is constantly facing new lawsuits. By contrast, things are going well in the Pharmaceuticals Division. At the JP Morgan Healthcare Conference, Stefan Oelrich, Head of the Pharmaceuticals Division, indicated the prospect of higher sales for a cardiac drug and a prostate cancer drug. Other blockbuster drugs are in the pipeline. For example, Asundexian, a treatment for strokes and heart attacks, is already in Phase III trials. The potential is estimated at around EUR 5 billion.

    Most recently, the Leverkusen-based company applied to the European Medicines Agency for approval of a higher dosage of the blockbuster Eylea. Studies have shown that higher doses combined with longer injection intervals can improve patients' vision. However, all this news is currently being lost because the investor Bluebell is causing all kinds of turmoil, first demanding the split-up of the group. Shortly afterwards, Jeff Ubben also got on board and demanded that an external person replace Bayer's CEO Werner Baumann and that the Supervisory Board be reappointed. Bluebell has now adopted these demands. The departure of Baumann in 2024 is considered certain.

    It seems, however, that Bluebell does not hold many shares; otherwise, this would have had to be reported. Irrespective of the disruptive fire from investors, Bayer's stock is doing extremely well this year. Since the beginning of the year, it has risen by more than 20%. The share is currently trading at EUR 58.21. From a purely fundamental point of view, the stock is still cheap, with a price-earnings ratio of around 7. Other pharmaceutical companies have significantly higher multiples. The discount is due to the Monsanto problems. If the lawsuits come to an end, the share can rise further.

    The biotech and pharma sectors offer a lot of potential because the population is getting older, and thus the number of diseases is increasing. Cardiovascular diseases and cancer are on the rise. These markets offer great opportunities. BioNTech is primarily targeting the fight against cancer. Cardiol Therapeutics focuses on cardiovascular diseases. Bayer is broadly positioned in the pharmaceuticals sector and covers the growing trend toward self-medication with Consumer Health.

    Conflict of interest

    Pursuant to §85 of the German Securities Trading Act (WpHG), we point out that Apaton Finance GmbH as well as partners, authors or employees of Apaton Finance GmbH (hereinafter referred to as "Relevant Persons") may hold shares or other financial instruments of the aforementioned companies in the future or may bet on rising or falling prices and thus a conflict of interest may arise in the future. The Relevant Persons reserve the right to buy or sell shares or other financial instruments of the Company at any time (hereinafter each a "Transaction"). Transactions may, under certain circumstances, influence the respective price of the shares or other financial instruments of the Company.

    In addition, Apaton Finance GmbH is active in the context of the preparation and publication of the reporting in paid contractual relationships.

    For this reason, there is a concrete conflict of interest.

    The above information on existing conflicts of interest applies to all types and forms of publication used by Apaton Finance GmbH for publications on companies.

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    Der Autor

    Armin Schulz

    Born in Mönchengladbach, he studied business administration in the Netherlands. In the course of his studies he came into contact with the stock exchange for the first time. He has more than 25 years of experience in stock market business.

    About the author

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