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August 18th, 2022 | 10:28 CEST

Defence Therapeutics CEO Sébastien Plouffe on the next steps in the battle against cancer

  • Expert
  • DefenceTherapeutics
  • Cancer
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A publicly traded biotechnology business called Defence Therapeutics is developing new vaccines and antibody-drug conjugates (ADC) products on its own proprietary platform. The ACCUM technology, which enables precise delivery of vaccine antigens or ADCs in their intact form to target cells, forms the basis of Defence Therapeutics' platform. As a result, catastrophic illnesses like cancer and infectious diseases can be combated with greater efficacy and potency. CEO Sébastien Plouffe gives us background on the company's latest development in the battle against cancer.

time to read: 1 minutes | Author: Mario Hose

Table of contents:

    Dr. Moutih Rafei, Director and VP of research and development, Defence Therapeutics
    "[...] At the end of 2022 or the beginning of 2023, we plan to start a Phase I study around each of our activities against breast cancer and skin cancer. [...]" Dr. Moutih Rafei, Director and VP of research and development, Defence Therapeutics

    Full interview


    What is the advantage of the latest discovery from Defence Therapeutics and when do patients benefit from the progress in the battle against cancer?

    ‘The battle against cancer includes multiple but specific strategies directly targeting the tumor itself (e.g., CAR-T or immune-checkpoint blockers). However, tumor regression alone is not enough as the tumor being targeted can re-grow and leads to the formation of metastases all over the body. To limit this outcome, one needs to develop a therapeutic cancer vaccine capable not only of destroying tumor cells, but also eliciting the formation of long-term memory response capable of providing potent protection from subsequent tumor relapses.

    So far, dendritic cell-based vaccines were ineffective at achieving this goal, which is why Defence Therapeutics chose to adopt a different and unconventional approach by reprogramming mesenchymal stromal cells using its Accum technology to obtain powerful antigen presenting cells.

    With such an experimental therapeutic vaccine in hand, Defence is currently preparing an IND submission to initiate a Phase I trial in patients with solid tumors.’

    Sébastien Plouffe, CEO, Defence Therapeutics Inc.

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    Der Autor

    Mario Hose

    Born and raised in Hannover, Lower Saxony follows social and economic developments around the globe. As a passionate entrepreneur and columnist he explains and compares the most diverse business models as well as markets for interested stock traders.

    About the author

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